A PLATFORM TRIAL APPROACH TO PROOF-OF-CONCEPT (POC) STUDIES IN AUTISM SPECTRUM DISORDER: AUTISM SPECTRUM POC INITIATIVE (ASPI)

A platform trial approach to proof-of-concept (POC) studies in autism spectrum disorder: Autism spectrum POC initiative (ASPI)

Background: Over C the past decade, autism spectrum disorder (ASD) research has blossomed, and multiple clinical trials have tested potential interventions, with varying results and no clear demonstration of efficacy.Lack of clarity concerning appropriate biological mechanisms to target and lack of sensitive, objective tools to identify subgroups a

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Anxiolytic effect of Korean Red Ginseng through upregulation of serotonin and GABA transmission and BDNF expression in immobilized mice

Background: Anxiolytic properties of Korean Red Ginseng (KRG) have been previously reported.However, the exact mechanism(s) of action remains to be elucidated.The present study investigated the effect of KRG on immobilization-induced anxiety-like behaviors in mice and explored the involvement of the serotonin and GABA systems and BDNF in the anxiol

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